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MouBeAT: A New and Open Toolbox for Guided Analysis of Behavioral Tests in Mice.

Bello-Arroyo E, Roque H, Marcos A, Orihuel J, Higuera-Matas A, Desco M, Caiolfa VR, Ambrosio E, Lara-Pezzi E, Gómez-Gaviro MV.

Front Behav Neurosci. 2018 Sep 7;12:201. doi: 10.3389/fnbeh.2018.00201. eCollection 2018.

Selective effects of Δ9-tetrahydrocannabinol on medium spiny neurons in the striatum.

Fernández-Cabrera MR, Higuera-Matas A, Fernaud-Espinosa I, DeFelipe J, Ambrosio E, Miguéns M.

PLoS One. 2018 Jul 26;13(7):e0200950. doi: 10.1371/journal.pone.0200950. eCollection 2018.

Mu-Opioid Receptors in Ganglia, But Not in Muscle, Mediate Peripheral Analgesia in Rat Muscle Pain.

Bagues A, Martín MI, Higuera-Matas A, Esteban-Hernández J, Ambrosio E, Sánchez-Robles EM.

Anesth Analg. 2018 Apr;126(4):1369-1376. doi: 10.1213/ANE.0000000000002717.

Investigation on the combined effect of cocaine and ethanol administration through a liquid chromatography-mass spectrometry metabolomics approach.

Sánchez-López E, Marcos A, Ambrosio E, Mayboroda OA, Marina ML, Crego AL.

J Pharm Biomed Anal. 2017 Jun 5;140:313-321. doi: 10.1016/j.jpba.2017.03.061. Epub 2017 Mar 31.

Lewis and Fischer 344 rats as a model for genetic differences in spatial learning and memory: Cocaine effects.

Fole A, Miguéns M, Morales L, González-Martín C, Ambrosio E, Del Olmo N.

Prog Neuropsychopharmacol Biol Psychiatry. 2017 Jun 2;76:49-57. doi: 10.1016/j.pnpbp.2017.02.024. Epub 2017 Mar 2.


Extended-access methamphetamine self-administration elicits neuroinflammatory response along with blood-brain barrier breakdown.

Gonçalves J, Leitão RA, Higuera-Matas A, Assis MA, Coria SM, Fontes-Ribeiro C, Ambrosio E, Silva AP.

Brain Behav Immun. 2017 May;62:306-317. doi: 10.1016/j.bbi.2017.02.017. Epub 2017 Feb 24.

Parafascicular thalamic nucleus deep brain stimulation decreases NMDA receptor GluN1 subunit gene expression in the prefrontal cortex.

Fernández-Cabrera MR, Selvas A, Miguéns M, Higuera-Matas A, Vale-Martínez A, Ambrosio E, Martí-Nicolovius M, Guillazo-Blanch G.

Neuroscience. 2017 Apr 21;348:73-82. doi: 10.1016/j.neuroscience.2017.02.009. Epub 2017 Feb 16.

Enantioseparation of the constituents involved in the phenylalanine-tyrosine metabolic pathway by capillary electrophoresis tandem mass spectrometry.

Sánchez-López E, Marcos A, Ambrosio E, Marina ML, Crego AL.

J Chromatogr A. 2016 Oct 7;1467:372-382. doi: 10.1016/j.chroma.2016.06.053. Epub 2016 Jun 17.

Unaltered cocaine self-administration in the prenatal LPS rat model of schizophrenia.

Santos-Toscano R, Borcel É, Ucha M, Orihuel J, Capellán R, Roura-Martínez D, Ambrosio E, Higuera-Matas A.

Prog Neuropsychopharmacol Biol Psychiatry. 2016 Aug 1;69:38-48. doi: 10.1016/j.pnpbp.2016.04.008. Epub 2016 Apr 16.

Rat-strain dependent changes of dendritic and spine morphology in the hippocampus after cocaine self-administration.

Selvas A, Coria SM, Kastanauskaite A, Fernaud-Espinosa I, DeFelipe J, Ambrosio E, Miguéns M.

Addict Biol. 2017 Jan;22(1):78-92. doi: 10.1111/adb.12294. Epub 2015 Sep 2.

Decreased rates of operant food self-administration are associated with reward deficits in high-fat feeding mice.

Íbias J, Miguéns M, Del Rio D, Valladolid-Acebes I, Stucchi P, Ambrosio E, Martín M, Morales L, Ruiz-Gayo M, Del Olmo N.

Eur J Nutr. 2016 Jun;55(4):1615-22. doi: 

Long-term consequences of perinatal and adolescent cannabinoid exposure on neural and psychological processes.

Higuera-Matas A, Ucha M, Ambrosio E.

Neurosci Biobehav Rev. 2015 Aug;55:119-46. doi: 10.1016/j.neubiorev.2015.04.020. Epub 2015 May 8. Review.

Strain differences in the expression of endocannabinoid genes and in cannabinoid receptor binding in the brain of Lewis and Fischer 344 rats.

Coria SM, Roura-Martínez D, Ucha M, Assis MA, Miguéns M, García-Lecumberri C, Higuera-Matas A, Ambrosio E.

Prog Neuropsychopharmacol Biol Psychiatry. 2014 Aug 4;53:15-22. doi: 10.1016/j.pnpbp.2014.02.012. Epub 2014 Mar 6.

The effects of cocaine self-administration on dendritic spine density in the rat hippocampus are dependent on genetic background.

Miguéns M, Kastanauskaite A, Coria SM, Selvas A, Ballesteros-Yañez I, DeFelipe J, Ambrosio E.

Cereb Cortex. 2015 Jan;25(1):56-65. doi: 10.1093/cercor/bht200. Epub 2013 Aug 21.

Sex-dependent changes in brain CB1R expression and functionality and immune CB2R expression as a consequence of maternal deprivation and adolescent cocaine exposure.

Llorente-Berzal A, Assis MA, Rubino T, Zamberletti E, Marco EM, Parolaro D, Ambrosio E, Viveros MP.

Pharmacol Res. 2013 Aug;74:23-33. doi: 10.1016/j.phrs.2013.05.001. Epub 2013 May 14.


Cocaine self-administration differentially modulates the expression of endogenous cannabinoid system-related proteins in the hippocampus of Lewis vs. Fischer 344 rats.

Rivera P, Miguéns M, Coria SM, Rubio L, Higuera-Matas A, Bermúdez-Silva FJ, de Fonseca FR, Suárez J, Ambrosio E.

Int J Neuropsychopharmacol. 2012 Dec 10:1-17. [Epub ahead of print]

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CNR1 gene deletion affects the density of endomorphin-2 binding sites in the mouse brain in a hemisphere-specific manner.

Paldy E, Borcel E, Higuera-Matas A, López-Montoya G, Wenger T, Toth G, Borsodi A, Ambrosio E.

Eur J Pharmacol. 2013 Jan 5;698(1-3):220-7. doi: 10.1016/j.ejphar.2012.10.043. Epub 2012 Nov 6.


Immunoglobulin G Fc receptor deficiency prevents Alzheimer-like pathology and cognitive impairment in mice.

Fernandez-Vizarra P, Lopez-Franco O, Mallavia B, Higuera-Matas A, Lopez-Parra V, Ortiz-Muñoz G, Ambrosio E, Egido J, Almeida OF, Gomez-Guerrero C.

Brain. 2012 Sep;135(Pt 9):2826-37. doi: 10.1093/brain/aws195.


Sex-specific disturbances of the glutamate/GABA balance in the hippocampus of adult rats subjected to adolescent cannabinoid exposure.

Higuera-Matas A, Miguéns M, Coria SM, Assis MA, Borcel E, del Olmo N, Ambrosio E.

Neuropharmacology. 2012 Apr;62(5-6):1975-84. doi: 10.1016/j.neuropharm.2011.12.028. Epub 2012 Jan 8.


Genetic differences in the modulation of accumbal glutamate and γ-amino butyric acid levels after cocaine-induced reinstatement.

Miguéns M, Botreau F, Olías O, Del Olmo N, Coria SM, Higuera-Matas A, Ambrosio E.

Addict Biol. 2011 Oct 18. doi: 10.1111/j.1369-1600.2011.00404.x. [Epub ahead of print]

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Effects of chronic cocaine administration on spatial learning and hippocampal spine density in two genetically different strains of rats.

Fole A, González-Martín C, Huarte C, Alguacil LF, Ambrosio E, Del Olmo N.

Neurobiol Learn Mem. 2011 May;95(4):491-7. doi: 10.1016/j.nlm.2011.02.012. Epub 2011 Mar 1.

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Individual differences in schedule-induced polydipsia: neuroanatomical dopamine divergences.

Pellón R, Ruíz A, Moreno M, Claro F, Ambrosio E, Flores P.

Behav Brain Res. 2011 Feb 2;217(1):195-201. doi: 10.1016/j.bbr.2010.10.010. Epub 2010 Oct 23.

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Chronic cannabinoid administration to periadolescent rats modulates the metabolic response to acute cocaine in the adult brain.

Higuera-Matas A, Soto-Montenegro ML, Montoya GL, García-Vázquez V, Pascau J, Miguéns M, Del Olmo N, Vaquero JJ, García-Lecumberri C, Desco M, Ambrosio E.

Mol Imaging Biol. 2011 Jun;13(3):411-5. doi: 10.1007/s11307-010-0388-8. Erratum in: Mol Imaging Biol. 2011 Aug;13(4):800

Strain differences in the dose-response relationship for morphine self-administration and impulsive choice between Lewis and Fischer 344 rats.

García-Lecumberri C, Torres I, Martín S, Crespo JA, Miguéns M, Nicanor C, Higuera-Matas A, Ambrosio E.

J Psychopharmacol. 2011 Jun;25(6):783-91. doi: 10.1177/0269881110367444. Epub 2010 May 20.

Higuera-Matas A, Botreau F, MIGUÉNS M, Del Olmo N, Borcel E, Pérez-Alvarez L, García-Lecumberri C, Ambrosio E (2009). Chronic periadolescent cannabinoid treatment enhances adult hippocampal PSA-NCAM expression in male Wistar rats but only has marginal effects on anxiety, learning and memory. Pharmacol Biochem Behav. Oct;93(4):482-90.


  Sánchez-Cardoso P, Higuera-Matas A, Martín S, MIGUÉNS M, Del Olmo N, García-Lecumberri C, Ambrosio E (2009). Strain differences between Lewis and Fischer 344 rats in the modulation of dopaminergic receptors after morphine self-administration and during extinction. Neuropharmacology. Jul;57(1):8-17.


·      M. MIGUÉNS, J.A. Crespo, N. Del Olmo, A. Higuera-Matas, G. López Montoya, C. García-Lecumberri, E. Ambrosio (2008). Differential modulation of glutamate and dopamine transporters during abstinence in contingently and non-contingently cocaine administered rats.Neuropharmacology. Oct;55(5):771-9.


·      M. MIGUÉNS, N. Del Olmo, A. Higuera-Matas, I. Torres, C. García-Lecumberri, E. Ambrosio (2008). Glutamate levels in the nucleus accumbens during cocaine self-administration and its extinction: a time course microdialysis study.Psychopharmacology196 (2):303-313.


·      Ballesteros-Yanez I, Ambrosio E, Pérez J, Torres I, MIGUÉNS M, García-Lecumberri C, Defelipe J (2008). Morphine self-administration effects on the structure of cortical pyramidal cells in addiction-resistant rats.Brain Research. Sep 16;1230:61-72.


·      Biscaia, M., Fernández, B., Higuera-Matas, A., MIGUÉNS, M., Viveros, M.P., García-Lecumberri C., Ambrosio, A (2008). Sex-dependent effects of a periadolescent exposure to the cannabinoid agonist cp-55,940 on morphine self-administration behavior and endogenous opioid system. Neuropharmacology 54:863-873.


·      Higuera-Matas, A., Soto-Montenegro, M.L., Del Olmo, N. MIGUÉNS, M., Torres, I., Vaquero, J.J., Sánchez, J., García-Lecumberri, C., Desco, M., and Ambrosio, E (2008).Augmented acquisition of cocaine self-administration and altered brain glucose metabolism in adult female but not male rats exposed to a cannabinoid agonist during adolescence. Neuropsychopharmacology 33(4):806-13.


·      N. Del Olmo*, A. Higuera-Matas*, M. MIGUÉNS, C. G. Lecumberri, E. Ambrosio (2007).Cocaine self-administration improves performance in a high demanding watermaze task. Psychopharmacology 195(1):19-25.

En este artículo la primera autoría es compartida


·      Ballesteros-Yañez, I., Ambrosio, E., Benavides-Piccione, R., Pérez, J., Torres, I., MIGUENS, M., García-Lecumberri, C., DeFelipe, J.(2007).The Effects of Morphine Self-Administration on Cortical Pyramidal Cell Structure in Addiction-Prone Lewis Rats. Cerebral Cortex 17(1): 238-49.


·      Sáchez-Cardoso, Pilar., Higuera-Matas, Alejandro., Martín, Sonsoles., Del Olmo, Nuria., MIGUÉNS, MIGUEL., Garcia-Lecumberri, C., Ambrosio, E. (2007). Modulation of the endogenous opioid system alter morphine self-administration and during its extinction: A Study in Lewis and Fischer 344 rats.Neuropharmacology 52: 931-948.


·      Nuria del Olmo, MIGUEL MIGUÉNS, Alejandro Higuera-Matas, Isabel Torres, Carmen García-Lecumberri, José María Solís, Emilio Ambrosio (2006). Hippocampal long-term potentiation is enhanced after extinction of cocaine self-administration.Brain Research 1116(1):120-26.


·      Del Olmo, N., Higuera-Matas A., MIGUÉNS M., García-Lecumberri C., Borcel E., Solís, J.M., Ambrosio E (2006).Hippocampal synaptic plasticity and water maze learning in cocaine self-administered rats. Annals of the New York Academy of Sciences. V. 1074:427-37